Innate immunity of the newborn: basic mechanisms and clinical correlates
Top Cited Papers
- 1 May 2007
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 7 (5), 379-390
- https://doi.org/10.1038/nri2075
Abstract
The fetus and newborn face a complex set of immunological demands, including protection against infection, avoidance of harmful inflammatory immune responses that can lead to pre-term delivery, and balancing the transition from a sterile intra-uterine environment to a world that is rich in foreign antigens. These demands shape a distinct neonatal innate immune system that is biased against the production of pro-inflammatory cytokines. This bias renders newborns at risk of infection and impairs responses to many vaccines. This Review describes innate immunity in newborns and discusses how this knowledge might be used to prevent and treat infection in this vulnerable population.Keywords
This publication has 157 references indexed in Scilit:
- Expression of mucosal chemokines TECK/CCL25 and MEC/CCL28 during fetal development of the ovine mucosal immune systemImmunology, 2007
- Reduced ability of newborns to produce CCL3 is associated with increased susceptibility to perinatal human immunodeficiency virus 1 transmissionJournal of General Virology, 2006
- Interaction of Neonatal Phagocytes with Group B Streptococcus: Recognition and ResponseInfection and Immunity, 2006
- Oral and Intraperitoneal Administration of Phosphorothioate Oligodeoxynucleotides Leads to Control ofCryptosporidium parvumInfection in Neonatal MiceThe Journal of Infectious Diseases, 2006
- Elevated Circulating IL-1and TNF-Alpha, and Unaltered IL-6 in First-Trimester Pregnancies Complicated by Threatened Abortion With an Adverse OutcomeMediators of Inflammation, 2006
- Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsNature, 2006
- Postnatal acquisition of endotoxin tolerance in intestinal epithelial cellsThe Journal of Experimental Medicine, 2006
- Newer approaches to the diagnosis of early onset neonatal sepsisArchives of Disease in Childhood: Fetal & Neonatal, 2005
- TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like ProteinScience, 2005
- Toll‐like receptor signaling inhibits structural development of the distal fetal mouse lungDevelopmental Dynamics, 2005