IgM antibody to filarial antigens in human cord blood: possibility of transplacental infection
- 1 January 1980
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 74 (4), 542-544
- https://doi.org/10.1016/0035-9203(80)90075-9
Abstract
In a hospital in Sri Lanka, antifilarial antibody in maternal and umbilical cord blood was determined by indirect immunofluorescence, enzyme-linked immunosorbent assay and radio-immunoassay. Anti-filarial antibody was detected in 18 of 340 cord blood samples. Specific IgM antibody was detected in 12 cord blood samples. The foetal IgM antibody was probably in response to a transplacental transfer of filarial antigens. The exposure of the foetus to filarial antigens might be beneficial, increasing resistance to infection, or detrimental by inducing at least partial tolerance.Keywords
This publication has 5 references indexed in Scilit:
- Infections and Intrauterine Growth RetardationPediatric Clinics of North America, 1970
- The Fluorescent Antibody Test in the Serological Diagnosis of the Causative Organisms of Tropical Eosinophilia and FilariasisJournal of Helminthology, 1968
- Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific ActivityNature, 1962
- Further Observations on Prenatal Hookworm Infection of DogsJournal of Parasitology, 1935
- Prenatal Infection with the Dog Hookworm, Ancylostoma caninumJournal of Parasitology, 1932