X-CHROMOSOME INACTIVATION IN HUMAN LIVER - CONFIRMATION OF X-LINKAGE OF ORNITHINE TRANSCARBAMYLASE
- 1 January 1976
- journal article
- research article
- Vol. 28 (4), 332-338
Abstract
Histochemical assay for ornithine transcarbamylase (OTC) activity in fixed frozen hepatic sections from a woman heterozygous for OTC deficiency revealed 2 populations of hepatocytes: those with normal activity and those with no activity. This confirms the hypothesis that the gene for OTC is X-linked. It also provides the 1st cytologic demonstration of cellular mosaicism for a liver-specific cell product.This publication has 23 references indexed in Scilit:
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