Pseudohermaphrodite Rat: End Organ Insensitivity to Testosterone
- 20 February 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 167 (3921), 1136-1137
- https://doi.org/10.1126/science.167.3921.1136
Abstract
The pseudohermaphrodite rat is characterized by lack of androgen-dependent differentiation. Treatment of these rats with testosterone failed to produce the expected changes in preputial and adrenal gland weights and hexobarbital metabolism. This insitivity of the end organ to testosterone could not be explained by defective formation of dihydrotestosterone.Keywords
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