Applications of Perfluorinated Compounds as Contrast Agents in Computed Tomography

Abstract

Perfluorohexylbromide, a nonionic and biologically inert radiodense compound, was evaluated as a potential contrast agent. Pulmonary and gastrointestinal administration of the neat liquid form was tested in dogs in conjunction with computed tomographic body scans. Contrast enhancement was demonstrable in 1 organ, the spleen, within 6 h of gastrointestinal administration of perfluorohexylbromide.