Platelet transfusion prophylaxis for patients with haematological malignancies: where to now?

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Abstract
National guidelines for platelet transfusion in many countries recommend that the general platelet transfusion trigger for prophylaxis is 10 × 109/l. This annotation reviews the evidence for this threshold level and discusses other current unresolved issues relevant to platelet transfusion practice such as the optimal dose and the clinical benefit of a strategy for the prophylactic use of platelet transfusions when the platelet count falls below a given threshold.