Androgens and Erythropoiesis

Abstract

DURING the past eight years androgen therapy has proved to be efficacious for the anemia of myelofibrosis with myeloid metaplasia.^{1 2 3} Although our initial report on this subject presented data showing improvement in circulating hemoglobin concentration in the first 9 patients treated² our subsequent experience has been less fortunate. There is no doubt that some patients with this disorder do not respond favorably to androgen therapy. A few who do not respond favorably may actually worsen as a result of therapy. The purpose of this communication is to present clinical and erythrokinetic data gathered in a group of 21 patients. The . . .