A COMPARISON OF THE PITUITARY INHIBITORY EFFECTS OF PREDNISONE, PREDNISOLONE, AND HYDROCORTISONE
Open Access
- 1 March 1958
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 13 (1), 98-102
- https://doi.org/10.1111/j.1476-5381.1958.tb00199.x
Abstract
Prednisone, prednisolone and hydrocortisone, administered in doses of 1 mg. daily for thirty days, depressed the growth rate of rats. Prednisolone and hydrocortisone caused atrophy of the adrenal glands and increased the relative weights of the thyroid glands and testes. The apparently similar effects produced by prednisone were not significant. The seminal vesicles were not affected significantly by prolonged administration of prednisone, prednisolone or hydrocortisone. Pretreatment of rats with these steroids prevented the adrenal ascorbic acid depletion normally caused by laparotomy under ether anaesthesia. Prednisolone was slightly more potent and prednisone was considerably less potent than hydrocortisone in producing these effects.Keywords
This publication has 14 references indexed in Scilit:
- Adrenocorticotrophic Hormone in the Blood of Adrenalectomized RatsNature, 1958
- METABOLIC EFFECTS OF METACORTANDRALONE AND METACORTANDRACINAnnals of the New York Academy of Sciences, 1955
- A MODIFIED ADRENAL ASCORBIC ACID DEPLETION TECHNIQUE FOR THE BIOASSAY OF ACTHJournal of Endocrinology, 1955
- THE EFFECT OF DESOXYCORTICOSTERONE ACETATE ON THE RELEASE OF ADRENOCORTICOTROPHIN BY THE PITUITARY GLANDBritish Journal of Pharmacology and Chemotherapy, 1953
- PRODUCTION OF REVERSIBLE HYPERADRENOCORTINISM IN RATS BY PROLONGED ADMINISTRATION OF CORTISONEEndocrinology, 1950
- THE ASSAY OF ADRENOCORTICOTROPHIC HORMONE BY THE ADRENAL ASCORBIC ACID-DEPLETION METHOD1Endocrinology, 1948
- REGULATION OF PITUITARY ADRENOCORTICOTROPHIC ACTIVITY DURING THE RESPONSE OF THE RAT TO ACUTE STRESS1Endocrinology, 1947
- THE PRODUCTION OF GLYCOSURIA IN THE NORMAL RAT BY MEANS OF 17-HYDROXY-2-DEHYDROCORTICOSTERONEEndocrinology, 1941
- Atrophy of the adrenal cortex in the rat produced by administration of large amounts of cortinThe Anatomical Record, 1938
- ATROPHY OF THE ADRENAL CORTEX OF THE RAT PRODUCED BY THE ADMINISTRATION OF LARGE AMOUNTS OF CORTINScience, 1937