Effects of Age, Strain, and Dietary Carbohydrate on the Hepatic Metabolism of Male Rats
- 1 February 1979
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 109 (2), 261-271
- https://doi.org/10.1093/jn/109.2.261
Abstract
The effects of age and the duration of feeding either a 65% sucrose or a 65% starch diet to normolipemic Wistar and potentially hyperlipemic-hyperglycemic BHE male rats on hepatic metabolite levels, calculated redox and phosphorylation states were studied. Consistent with previous reports, the feeding of sucrose to BHE rats hastened the appearance of hyperlipemia while having little effect in Wistar rats. The changes in hepatic metabolites were consistent with an increased hepatic lipogenesis in BHE rats. The results suggest that the effects of feeding sucrose to BHE rats potentiate the genetically increased hepatic lipogenesis in these rats.Keywords
This publication has 26 references indexed in Scilit:
- Coordinate control of intermediary metabolism in rat liver by the insulin/glucagon ratio during starvation and after glucose refeedingArchives of Biochemistry and Biophysics, 1977
- Comparative studies on lipogenesis and cholesterogenesis in lipemic BHE rats and normal wistar ratsArchives of Biochemistry and Biophysics, 1977
- Pathological Changes During Aging in, Barrier-Reared Fischer 344 Male RatsJournal of Gerontology, 1977
- Influences of intracellular pyridine nucleotide redox states on fatty acid synthesis in isolated rat hepatocytesArchives of Biochemistry and Biophysics, 1977
- Ribosome editing and the error catastrophe hypothesis of cellular agingMechanisms of Ageing and Development, 1977
- Aging and the alteration of enzymes: A reviewMechanisms of Ageing and Development, 1975
- Metabolic abnormalities in BHE ratsDiabetologia, 1974
- The problem of tissue sampling from experimental animals with respect to freezing technique, anoxia, stress and narcosisArchives of Biochemistry and Biophysics, 1972
- The distribution of hepatic metabolites and the control of the pathways of carbohydrate metabolism in animals of different dietary and hormonal statusArchives of Biochemistry and Biophysics, 1971
- Effect of Age on Oxidative Phosphorylation in the RatJournal of Gerontology, 1968