Genetic Animal Models of Alcohol and Drug Abuse
- 17 June 1994
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 264 (5166), 1715-1723
- https://doi.org/10.1126/science.8209252
Abstract
Behavioral and pharmacological responses of selectively bred and inbred rodent lines have been analyzed to elucidate many features of drug sensitivity and the adverse effects of drugs, the underlying mechanisms of drug tolerance and dependence, and the motivational states underlying drug reward and aversion. Genetic mapping of quantitative trait loci (QTLs) has been used to identify provisional chromosomal locations of genes influencing such pharmacological responses. Recent advances in transgenic technology, representational difference analysis, and other molecular methods now make feasible the positional cloning of QTLs that influence sensitivity to drugs of abuse. This marks a new period of synthesis in pharmacogenetic research, in which networks of drug-related behaviors, their underlying pharmacological, physiological, and biochemical mechanisms, and particular genomic regions of interest are being identified.Keywords
This publication has 111 references indexed in Scilit:
- Quantitative trait loci (QTL) applications to substances of abuse: Physical dependence studies with nitrous oxide and ethanol in BXD miceBehavior Genetics, 1993
- Selective breeding, congenic strains, and other classical genetic approaches to the analysis of alcohol-related polygenic pleiotropismsBehavior Genetics, 1993
- Selective breeding for alcohol withdrawal severityBehavior Genetics, 1993
- Selective breeding for alcohol preference and associated responsesBehavior Genetics, 1993
- Empirical estimates of bonferroni corrections for use in chromosome mapping studies with the BXD recombinant inbred strainsBehavior Genetics, 1992
- Use of recombinant inbred strains to detect quantitative trait loci associated with behaviorBehavior Genetics, 1991
- Pharmacogenetics of Drugs of AbuseAnnals of the New York Academy of Sciences, 1989
- Further characterization of benzodiazepine receptor differences in long-sleep and short-sleep miceLife Sciences, 1988
- Why does a sucrose choice reduce the consumption of alcohol in C57BL/6J mice?Life Sciences, 1987
- Gamma-aminobutyric acid and alcohol actions: Neurochemical studies of long sleep and short sleep miceLife Sciences, 1986