Further Observations on Whether Host Immunodepression is Associated with Tumour Growth in Mice

Abstract

In order to investigate whether the presence of a tumour was associated with immunodepression in the host, spleen cells from parent line animals with tumours were injected intravenously into F₁ hybrids, half of which carried the same tumour. Further groups of F₁ hybrid with and without the tumour received spleen cells from non-tumour bearing parent line animals. The G.V.H. reactions induced in the four groups of F₁ hybrid were compared and no significant differences were found. This was true in separate experiments, involving two mammary carcinomata and a 3-methylcholanthrene induced sarcoma, wherein the period of tumour growth in the parent line donor and F₁ hybrid recipient was varied.