Abstract
Power calculations are derived form matched case-control studies in terms of the probability po of exposure among the control patients, the correlation coefficient .vphi. for exposure between matched case and control patients, and the odds ratio .psi. for exposure in case and control patients. For given Type I and Type II error probabilities .alpha. and .beta., the odds ratio that can be detected with a given sample size is derived as well as the sample size needed to detect a specified value of the odds ratio. Graphs are presented for paired designs that show the relationship between sample size and power for .alpha.=.05, .beta.=.2, and different values of po, .vphi., and .psi.. The sample size needed for designs involving M matched control patients can be derived from these graphs by means of a simple equation. These results quantify the loss of power associated with increasing correlation between the exposure status of matched case and control patients. Sample size requirements are also greatly increased for values of po near 0 or 1. The relationship between sample size, .psi., .vphi., and po is discussed and illustrated by examples.

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