Double-blind clinical comparison between a gastrin-receptor antagonist, proglumide, and a histamine H2-blocker, cimetidine
- 1 January 1978
- journal article
- clinical trial
- Published by Informa Healthcare in Current Medical Research and Opinion
- Vol. 5 (5), 376-382
- https://doi.org/10.1185/03007997809111901
Abstract
A double-blind trial was carried out in 30 patients with peptic ulcers to assess the effects of treatment with a gastrin-receptor antagonist, proglumide, compared with a histamine H2-blocker, cimetidine. Patients received either 1200 mg proglumide or 1200 mg cimetidine per day for 28 days. The results showed that both drugs significantly reduced clinical symptoms and gastric secretion. In patients treated with cimetidine, there was a significant increase in blood gastrin levels and marked hypertrophy and hyperplasia of the antral mucosa was observed in almost all patients. No such changes were found in the patients treated with proglumide.Keywords
This publication has 5 references indexed in Scilit:
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- TREATMENT OF DUODENAL ULCER WITH CIMETIDINEThe Lancet, 1976
- CIMETIDINE, METIAMIDE AND GASTRIC ULCERThe Lancet, 1976
- H_2-Receptor Antagonists in the Treatment of Peptic UlcerAnnals of Internal Medicine, 1976
- Inhibition of Gastric Acid Secretion by Cimetidine in Patients with Duodenal UlcerNew England Journal of Medicine, 1975