Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41
- 11 March 2005
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 20,p. 2552-2554
- https://doi.org/10.1039/b419015g
Abstract
We present a straightforward and high yielding method to synthesize constrained helical peptides via thioether ligation; this method represents an attractive alternative to the formation of lactam bridge constraints to induce helicity in peptides.Keywords
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