Cultured Epidermis for the Coverage of Massive Burn Wounds
- 1 June 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Annals of Surgery
- Vol. 211 (6), 676-680
- https://doi.org/10.1097/00000658-199006000-00005
Abstract
Seven patients with a mean burn size of 69.6% total body-surface area underwent skin grafting with autologous cultured epidermis. They were compared with a historical group of 18 controls, with a mean burn size of 60%, who underwent grafting with conventional meshed split-thickness autograft. There were no statistically significant differences between the two groups in length of hospital stay, total number of surgical operations, or cost. There were no deaths and two major complications in the cultured epidermis group; there were six deaths and 11 major complications in the historical control group. Because of this encouraging early experience, a prospective, randomized study is now in order to evaluate this technology.Keywords
This publication has 13 references indexed in Scilit:
- BIOLOGIC ATTACHMENT, GROWTH, AND DIFFERENTIATION OF CULTURED HUMAN EPIDERMAL-KERATINOCYTES ON A GRAFTABLE COLLAGEN AND CHONDROITIN-6-SULFATE SUBSTRATE1988
- USE OF CULTURED EPIDERMAL AUTOGRAFTS AND DERMAL ALLOGRAFTS AS SKIN REPLACEMENT AFTER BURN INJURYThe Lancet, 1986
- LONG-TERM SKIN ALLOGRAFT SURVIVAL AFTER SHORT-TERM CYCLOSPORIN TREATMENT IN A PATIENT WITH MASSIVE BURNSThe Lancet, 1986
- Permanent Coverage of Large Burn Wounds with Autologous Cultured Human EpitheliumNew England Journal of Medicine, 1984
- Successful Use of a Physiologically Acceptable Artificial Skin in the Treatment of Extensive Burn InjuryAnnals of Surgery, 1981
- GRAFTING OF BURNS WITH CULTURED EPITHELIUM PREPARED FROM AUTOLOGOUS EPIDERMAL-CELLS1981
- Growth of cultured human epidermal cells into multiple epithelia suitable for grafting.Proceedings of the National Academy of Sciences, 1979
- Temporary Skin Transplantation and Immunosuppression for Extensive BurnsNew England Journal of Medicine, 1974
- THE USE OF PIG SKIN AS A TEMPORARY BIOLOGICAL DRESSINGPlastic and Reconstructive Surgery, 1965
- THE MESH SKIN GRAFT.1964