EXPERIMENTAL STUDY ON NITROGLYCOL POISONING EFFECT OF NITROGLYCOL UPON THE HEART FUNCTIONS

Abstract

The toxic effect of nitroglycol upon the heart functions was investigated electro-cardiographically using rabbits injected subcutaneously with the poison. On the electro-cardiographic patterns thus obtained, some changes such as depression of ST, negative, low, and biphasic T were noticed by comparison with those obtained before the administra-tion of the poison, and these changes occured independently to the amount of methaemo-globin formed in the blood. The changes on the patterns disappeared at 24 hours after the injection, but when the poisoned rabbits were examined by the anoxia test method, the abnormal patterns above mentioned appeared again. This fact indicates that the effect of nitroglycol upon the heart tissues or the heart functions remained still, whilst no traces of nitroglycol were noticed in the blood. From these findings, the changes on the patterns of poisoned rabbits were assumed to be caused by the direct action of nitroglycol upon the heart functions.