Differences in the rates of aggregation of proteoglycans from human articular cartilage and chondrosarcoma
- 1 December 1983
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 215 (3), 705-708
- https://doi.org/10.1042/bj2150705
Abstract
Pieces of adult human articular cartilage and chondrosarcoma were incubated in the presence of [35S]sulfate. After continuous or pulse-change incorporation of radioactivity, proteoglycans were extracted with 4.0 M-guanidinium chloride, purified by equilibrium density-gradient centrifugation and fractionated by gel chromatography. A comparison of the results suggests that the formation of stable aggregates occurs at a lower rate in articular cartilage than in chondrosarcoma.This publication has 13 references indexed in Scilit:
- Delayed formation of proteoglycan aggregate structures in human articular cartilage disease statesNature, 1980
- Age-related changes in proteoglycan structureArchives of Biochemistry and Biophysics, 1979
- An oligosaccharide component in proteoglycans of articular cartilageBiochimica et Biophysica Acta (BBA) - General Subjects, 1979
- Biosynthesis of proteoglycans and their assembly into aggregates in cultures of chondrocytes from the Swarm rat chondrosarcoma.Journal of Biological Chemistry, 1979
- Age-related changes in the composition and structure of human articular-cartilage proteoglycansBiochemical Journal, 1978
- Isolation and characterization of proteoglycans from human chondrosarcomasJournal of Biological Chemistry, 1978
- Polydispersity of cartilage proteoglycans. Structural variations with size and buoyant density of the molecules.Journal of Biological Chemistry, 1977
- Distribution of keratan sulfate in cartilage proteoglycans.Journal of Biological Chemistry, 1977
- Histological and biochemical studies on cartilage from osteoarthrotic femoral heads with special reference to surface characteristics.1977
- Hyaluronic acid in cartilage and proteoglycan aggregationBiochemical Journal, 1974