Long term follow-up of bone mineral status in children with renal disease
- 1 January 1988
- journal article
- research article
- Published by Springer Nature in Pediatric Nephrology
- Vol. 2 (1), 22-26
- https://doi.org/10.1007/bf00870374
Abstract
Bone mineral content (BMC) was measured by photon absorptiometry in the non-dominant forearm of children with chronic renal failure followed for a total of 2472 months. From 48 children, 302 measurements were made, and changes which occurred in BMC over time were correlated with several factors. Patients were divided into those who had received glucocorticoids (group 1) and those who had not (group 2). Group 1 patients had a lower mean serum creatinine (Cr) (p0.02) and were more demineralized than group 2 patients. There was no correlation between BMC and height velocity or estimated creatinine clearance. BMC and height Z-score (SDS) were highly correlated. Over the period of study, group 1 patients remained shorter, had a lower height velocity, a lower BMC Z-score and a lower BMC for each serum creatinine level. Long-term therapeutic intervention with oral 1,25(OH)2D improved bone mineral status in three children in the nonsteroid group, but none of those in the steroid group. This study demonstrates that steroid administration is probably the most important factor causing bone demineralization, possibly even more important than renal failure.Keywords
This publication has 21 references indexed in Scilit:
- Effects of 1,25-Dihydroxyvitamin-D3 Treatment on Mineral Balance in Children with End Stage Renal Disease Undergoing Chronic HemofiltrationPediatric Research, 1986
- Aluminum loading in children with chronic renal failureKidney International, 1984
- Aluminum Intoxication from Aluminum-Containing Phosphate Binders in Children with Azotemia Not Undergoing DialysisNew England Journal of Medicine, 1984
- VITAMIN D: RECENT ADVANCESAnnual Review of Biochemistry, 1983
- AluminumAdvances in Clinical Chemistry, 1983
- Skeletal demineralization in Turner's syndromeCalcified Tissue International, 1982
- Bone status of children receiving anticonvulsant therapyMetabolic Bone Disease and Related Research, 1982
- FOREARM BONE MINERAL CONTENT IN CHILDREN Normative DataActa Paediatrica, 1981
- Bone mineral status in growth hormone deficiencyThe Journal of Pediatrics, 1980
- Effect of Prednisone on Growth and Bone Mineral Content in Childhood Glomerular DiseaseArchives of Pediatrics & Adolescent Medicine, 1978