Displaced cholinergic, GABAergic amacrine cells in the rabbit retina also contain adenosine
- 1 November 1989
- journal article
- Published by Cambridge University Press (CUP) in Visual Neuroscience
- Vol. 3 (5), 425-431
- https://doi.org/10.1017/s0952523800005927
Abstract
It is generally accepted that the purine nucleoside, adenosine, plays a neuromodulatory role in the central nervous system (CNS) (Daly et al., 1981; Phillis ' Wu, 1983; Williams, 1986; Williams, 1987; Snyder, 1985). Adenosine is thought to exert its primary effects presynaptically, by inhibiting the release of neurotransmitters including ³-aminobutyric acid (GABA) and acetylcholine (ACh) (Phillis ' Barraco, 1985; Proctor ' Dunwiddie, 1987). In mammalian retina, cell bodies that are strongly labeled for adenosine-like immunoreactivity (ALIR) have been localized to the ganglion cell layer (GCL) (Braas et al., 1987; Blazynski et al., 1989). Rabbit retinal cells that are labeled by markers for both ACh and GABA are located in the GCL and inner nuclear layer (INL) (Tauchi ' Masland, 1984; Vaney ' Young, 1988b; Brecha et al., 1988). It is now demonstrated in the rabbit retina that approximately 50% of the cells labeled for ALIR within the GCL represent true ganglion cells, with the remainder presumed to be displaced cholinergic amacrine cells (DAPI accumulating). In addition, some of these same cells also demonstrate immunoreactivity to glutamate decarboxylase (GAD), involved in the biosynthesis of the neurotransmitter GABA. Thus, in a particular class of retinal neurons, two fast-acting neurotransmitters as well as a putative neuromodulator have been co-localized.Keywords
This publication has 36 references indexed in Scilit:
- Comparison of adenosine uptake and endogenous adenosine-containing cells in mammalian retinaVisual Neuroscience, 1989
- GABA-like immunoreactivity in NADPH-diaphorase amacrine cells of the rabbit retinaBrain Research, 1988
- Cholinergic amacrine cells of the rabbit retina contain glutamate decarboxylase and gamma-aminobutyrate immunoreactivity.Proceedings of the National Academy of Sciences, 1988
- GABA-like immunoreactivity in cholinergic amacrine cells of the rabbit retinaBrain Research, 1988
- Endogenous adenosine and adenosine receptors localized to ganglion cells of the retina.Proceedings of the National Academy of Sciences, 1987
- Substance P-immunoreactive retinal ganglion cells and their central axon terminals in the rabbitNature, 1987
- Adenosine-mediated regulation of cyclic AMP levels in isolated incubated retinasBrain Research, 1986
- ‘Coronate’ amacrine cells in the rabbit retina have the ‘starburst’ dendritic morphologyProceedings of the Royal Society of London. B. Biological Sciences, 1984
- Regulation of dopamine- and adenosine-dependent adenylate cyclase systems of chicken embryo retina cells in culture.Proceedings of the National Academy of Sciences, 1982
- A quantitative comparison between the ganglion cell populations and axonal outflows of the visual streak and periphery of the rabbit retinaJournal of Comparative Neurology, 1980