Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.
Open Access
- 1 January 1986
- Vol. 27 (1), 78-85
- https://doi.org/10.1136/gut.27.1.78
Abstract
The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.This publication has 35 references indexed in Scilit:
- A new purification procedure for Clostridium difficile enterotoxinBiochemical and Biophysical Research Communications, 1984
- Clostridium difficile enterotoxin (toxin A): new resultsBiochemical Society Transactions, 1984
- Rapid death of infant rhesus monkeys injected with Clostridium difficile toxins A and B: Physiologic and pathologic basisThe Journal of Pediatrics, 1984
- TOXIN A OF CLOSTRIDIUM DIFFICILE: PRODUCTION, PURIFICATION AND EFFECT IN MOUSE INTESTINEActa Pathologica Microbiologica Scandinavica Series B: Microbiology, 1983
- Myoelectric Effects of Clostridium difficile: Motility-Altering Factors Distinct From Its Cytotoxin and Enterotoxin in RabbitsGastroenterology, 1982
- Cytotoxicity Assay in Antibiotic-Associated ColitisThe Journal of Infectious Diseases, 1979
- Identification of Clostridium difficile as a cause of pseudomembranous colitis.BMJ, 1978
- Clindamycin-Associated Colitis Due to a Toxin-Producing Species of Clostridium in HamstersThe Journal of Infectious Diseases, 1977
- Effect of Enterotoxins of Vibrio cholerae, Escherichia coli, and Shigella dysenteriae Type 1 on Fluid and Electrolyte Transport in the ColonThe Journal of Infectious Diseases, 1976
- EXPERIMENTAL CHOLERA A CANINE MODELThe Lancet, 1966