In-Vitro Effects of Clostridium Welchii Type-D Epsilon Toxin on Guinea-Pig, Mouse, Rabbit and Sheep Cells
- 1 August 1978
- journal article
- research article
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 11 (3), 299-302
- https://doi.org/10.1099/00222615-11-3-299
Abstract
SUMMARY Epsilon toxin, at relatively low concentrations, killed guinea-pig peritoneal macrophages in vitro. The cells became swollen, the nuclear and cytoplasmic membranes “blistered” and discontinuous, and the cytoplasm appeared structureless. Formalinised epsilon prototoxin was shown to bind closely to the outer surface of the cells and it is concluded that this site represents the location of the receptors for epsilon toxin. In addition the toxin at higher concentrations killed rabbit peritoneal macrophages after increased periods of incubation, but had no demonstrable effect on other cells from guinea-pigs, rabbits, mice and sheep.This publication has 4 references indexed in Scilit:
- Further Studies on the Mode of Action of Clostridium Welchii Type-D Epsilon ToxinJournal of Medical Microbiology, 1978
- The Use of An Immunoperoxidase Technique to Investigate by Light and Electron Microscopy the Sites of Binding of Clostridium Welchii Type-D Epsilon Toxin in MiceJournal of Medical Microbiology, 1978
- An investigation of the macrophage electrophoretic mobility test in the diagnosis of scrapie in sheepJournal of Comparative Pathology, 1977
- EFFECTS OF CHOLERA EXOTOXIN ON MITOCHONDRIAL MORPHOLOGY OF LYMPHOID-CELLS AND MONONUCLEAR PHAGOCYTES1976