Structure-Activity Relationship of Colistins.
- 1 January 1967
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 15 (8), 1219-1224
- https://doi.org/10.1248/cpb.15.1219
Abstract
Purified samples of polymyxin group antibiotics were effective antimicrobial agents against Escherichia coli. Removal of the C9-fatty acid from the colistin molecule resulted in the decrease of the activity. The side chain moiety itself showed no antimicrobial activity. The cyclic peptide moiety showed an antimicrobial activity although it was less active than the parent antibiotic. The active structure responsible for the antimicrobial activity is the cyclic peptide moiety in colistin molecule.This publication has 4 references indexed in Scilit:
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- A Culture Medium for Differentiating Organisms of Typhoid-Colon Aerogenes Groups and for Isolation of Certain Fungi: With Colored PlateThe Journal of Infectious Diseases, 1926