Vanadium-Catalyzed Addition of Propargyl Alcohols and Imines
- 25 July 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (32), 10358-10359
- https://doi.org/10.1021/ja064011p
Abstract
A Mannich-type addition of propargylic alcohols and N-methoxycarbonylimines has been achieved by using a vanadium catalyst. The reactivity of the vanadium catalyst could be modulated by modifying the silanol ligands to avoid the background reaction. The strategy described herein provides an atom-economical access to β-aryl-substituted Z-enones with an allylic amino functional group, which are not readily accessible with other methods.Keywords
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