Effect of Local X-Irradiation on Growth Capacity of Mouse Kidney

Publisher Website
Google Scholar
Abstract
In adult female CF No. 1 mice, kidney enlargement after unilateral nephrectomy is a consequence mainly of hypertrophy. New cell formation as evidenced by an increase in the total DNA content of the kidney may be a contributing factor in young animals but this becomes negligible with increasing age. The compensatory response occurring after uninephrectomy in the adult mouse is quite radioresistant, whether irradiation occurs immediately or 5 days post-operatively. This contrasts with the well-known radiosensitivity of cell renewal systems.