A Dextrorotatory Polysaccharide of Very High Anticoagulant Activity Newly Isolated From the Whale's Lung and Intestine

Abstract

A dextrorotatory polysaccharide recently isolated from whale lung and intestine was demonstrated to have a high anticoagulant activity, in vitro and in vivo. Protamine neutralization and lipolytic activities are similar to those of beef heparin. The S content of the new polysaccharide is lower than that of beef heparin. The new substance was used successfully as an anticoagulant in 221 dog perfusion experiments.