THE EFFECT OF LITHIUM AND RELATED METAL IONS ON THE URINARY EXCRETION OF 2‐OXOGLUTARATE AND CITRATE IN THE RAT
Open Access
- 1 February 1974
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 50 (2), 283-289
- https://doi.org/10.1111/j.1476-5381.1974.tb08574.x
Abstract
1 Administration of lithium ions to rats, either acutely by intraperitoneal injection or chronically in food, causes increased excretion of 2-oxoglutarate and citrate. 2 Chronic administration in food of rubidium and caesium causes decreased excretion of 2-oxoglutarate and citrate. 3 The effects described are not due to changes in urine volume, nor pH, nor are they simply related to the excretion of the injected ion. 4 Acute administration of lithium caused an increased level of 2-oxoglutarate in kidney and reduced the ratio of glutamate to 2-oxoglutarate. 5 Renal gluconeogenesis in slices was only slightly affected by either acute administration of lithium to the animals or by its presence in the incubation medium of renal slices.Keywords
This publication has 11 references indexed in Scilit:
- Biochemical Studies on the Effects of Lithium Salts: Excretion of Tricarboxylic Acid-Cycle Intermediary Metabolites, Inhibition of Vasopressin and Distribution of other Ions in the BodyBiochemical Society Transactions, 1973
- Lithium Ions and Insulin: Effects on Carbohydrate and Electrolyte MetabolismBiochemical Society Transactions, 1973
- Rubidium: Biochemical, Behavioral, and Metabolic Studies in HumansAmerican Journal of Psychiatry, 1973
- The effect of lithium salts on the urinary excretion of α‐oxoglutarate in manBritish Journal of Pharmacology, 1972
- Lithium and rubidium: a role in the affective disorders.1971
- Lithium in PsychiatryNature, 1971
- Rubidium and Lithium: Opposite Effects on Amine-Mediated ExcitementScience, 1971
- Lithium in psychiatric therapy and prophylaxisJournal of Psychiatric Research, 1968
- Renal gluconeogenesis. The effect of diet on the gluconeogenic capacity of rat-kidney-cortex slicesBiochemical Journal, 1963
- The effects of changes in acid‐base balance on urinary citrate in the ratThe Journal of Physiology, 1959