Alteration of amino acid content of cerebrospinal fluid from patients with epilepsy
- 1 December 1988
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 78 (6), 473-479
- https://doi.org/10.1111/j.1600-0404.1988.tb03690.x
Abstract
‐ The alteration of amino acids content in cerebrospinal fluids (CSF) from 31 cases of epilepsy and 10 cases of headache (as control) was studied using high performance liquid chromatography (HPLC). In patients with epilepsy, it was found that the CSF levels of GABA and aspartic acid had a tendency to decrease, but these changes were not statistically significant. In simple partial seizures, the CSF levels of glutamic acid and glycine also showed a tendency to decrease. The decrease of CSF GABA found in epileptics had a tendency to normalize following treatment with valproic acid. At the same time, administration of valproic acid induced a decrease of aspartic acid in the CSF of epileptics. These results suggest that administration of valproic acid may induce an increase in GABA and a decrease in aspartic acid in the CSF of epileptics.Keywords
This publication has 18 references indexed in Scilit:
- Increased concentrations of aspartic acid in the cerebrospinal fluid of patients with epilepsy and trigeminal neuralgia: an effect of medication?Acta Neurologica Scandinavica, 2009
- Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitisZeitschrift für Neurologie, 1983
- Cerebrospinal Fluid GABA MeasurementsClinical Neuropharmacology, 1983
- Relationship Between GABA Concentrations in Cerebrospinal Fluid and Seizure ExcitabilityJournal of Neurochemistry, 1982
- Amino acid abnormalities in epileptogenic fociNeurology, 1981
- Levels of -Aminobutyric Acid in Cerebrospinal Fluid in Various Neurologic DisordersArchives of Neurology, 1980
- Low cerebrospinal fluid γ‐aminobutyric acid content in seizure patientsNeurology, 1979
- γ‐Aminobutyric acid (GABA) in human cerebrospinal fluid: radioreceptor assayJournal of Neurochemistry, 1977
- FREE AMINO ACID LEVELS IN THE CEREBROSPINAL FLUID OF NORMAL HUMANS AND THEIR VARIATION IN CASES OF EPILEPSY AND SPIELMEYER‐VOGT‐BATTEN DISEASEJournal of Neurochemistry, 1974
- Amino acid content of epileptogenic human brain: Focal versus surrounding regionsBrain Research, 1972