STATISTICAL ANALYSIS OF FILTRATION RATE AND EFFECTIVE RENAL PLASMA FLOW RELATED TO WEIGHT AND SURFACE AREA IN DOGS

Abstract

The mean filtration rate in 75 normal, trained female dogs per sq. m. of body surface area is 84.4 cc./min. with a standard error of 2.2; range from 43 to 133 cc./min. Expressed per kg. of body wt. these figures are: mean 4.29, standard error 0.115, range 2.15 to 8.32 cc./min. The mean effective renal plasma flow (p-aminohippuric acid clearance) per sq. m. of body surface area is 266 cc./min. with a standard error of 7.6; range from 139 to 430 cc./min. Expressed per kg. of body wt. these figures are: mean 13.5, standard error 0.375, range 8.05 to 22.4 cc./min. The mean filtration fraction is 0.317, and the coeff. of correlation between plasma flow and filtration rate is 0.79 when related to surface area; 0,73, when related to body wt. The above statistics are compared with these in normal men. The dog has a higher filtration rate than man, but a smaller renal plasma flow when these functions are related to surface area.