Sodium Amylobarbitone and Responses to Nonreward*

Abstract

Three experiments are reported testing two alternative hypotheses concerning the behavioural effects of sodium amylobarbitone (SA): (1) that it blocks the after-effect of nonreward; (2) that it blocks conditioned frustration, elicited by stimuli associated with nonreward. In support of (2) Experiment I showed that SA given in acquisition abolished the partial reinforcement extinction effect (PREE) when rats were run at one trial a day in an alley for food reward on a continuous (CRF) or partial (PRF) reinforcement schedule. Experiment II showed that, in the goal section, the effect of the drug on the PREE was due to its presence during acquisition and was not due to state dependency; but the effect of the drug in the start section was consistent with state dependency of the PREE. In Experiment III, in opposition to (1) and again in support of (2), SA given to rats trained to show patterned running for water reward on a single alternation schedule blocked patterning by increasing running speeds on nonreward trials, not by decreasing running speeds on rewarded trials.