Lowered Glutathione‐Peroxidase Activity in Asthmatic Patients with Food and Aspirin Intolerance
- 1 January 1986
- Vol. 41 (1), 43-45
- https://doi.org/10.1111/j.1398-9995.1986.tb00273.x
Abstract
In analogy with findings from animal experiments, people with low glutathione peroxidase (GSH-Px) activity could be expected to have altered sensitivities to effects of drugs, chemical and possibly food. We have investigated GSH-Px activity in 12 patients with intrinsic asthma and food and aspirin intolerance. Ten of the 12 patients had very low or low GSH-Px activity and the frequency of low GSH-Px activity in this group was statistically significant (P < 0.001) compared with the control material of age- and sex-matched healthy individuals. Our finding of lowered GSH-Px activity in patients with aspirin intolerance may indicate the involvement of hitherto unknown mechanisms in the pathogenesis of asthmatic disorders.Keywords
This publication has 10 references indexed in Scilit:
- Pharmacology of free radicals; Recent views on their relation to inflammatory mechanismsLife Sciences, 1984
- Biological Activity of SeleniumAnnual Review of Nutrition, 1983
- Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitroNature, 1981
- Mediators of Immediate Hypersensitivity Derived from Arachidonic AcidNew England Journal of Medicine, 1980
- Acetylsalicylic asthma and migraine - a defect in serotonin (5-HT) uptake in plateletsThrombosis Research, 1978
- Glutathione peroxidase in dried blood spotsCellular and Molecular Life Sciences, 1978
- Prostaglandins and ThromboxanesAnnual Review of Biochemistry, 1978
- Acetylation of prostaglandin synthase by aspirin.Proceedings of the National Academy of Sciences, 1975
- Aspirin intolerance: II. A prospective study in an atopic and normal populationJournal of Allergy and Clinical Immunology, 1974
- Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular glandsBiochemistry, 1972