OBSERVATIONS ON A CASE OF ERYTHREMIC MYELOSIS
- 1 July 1960
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 53 (1), 207-215
- https://doi.org/10.7326/0003-4819-53-1-207
Abstract
A 48-year-old Bantu male presented with anemia, neutropenia, and thrombopenia, the bone marrow showing the features of erythremic myelosis. The cytoplasm of the normoblasts contained numerous periodic acid-Schiff (P. A. S.) positive granules. The serum vitamin B12 content was 575 uug/ml, and the mean cell life of the erythrocytes 17 days. Steroid therapy aided the control of hemorrhagic manifestations. The patient died 5 months later, with acute monoblastic leukemia. Serum vitamin B12 assay and P.A.S. staining of the marrow may aid in the diagnosis of erythremic myelosis.Keywords
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