N*-N*-S* Tridentate ligand system as potential antitumor agents

Abstract

Compounds containing an N*-N*-S* tridentate ligand were synthesized and tested for antitumor activity against P-388 lymphocytic leukemia in mice. Of these, only 2,2''-bipyridyl-6-carbothioamide (1a) showed antitumor activity at relatively high dosage levels. Compound 1a was also evaluated against L-1210 [leukemia] and S180 [sarcoma] cells in culture and found to have significant activity.