The Effect of Digitalis on the Cardiac Output of the Normal Heart at Rest and during Exercise
- 1 October 1961
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 55 (4), 620-631
- https://doi.org/10.7326/0003-4819-55-4-620
Abstract
There is a prevalent feeling among physicians that digitalis is toxic to the compensated heart. As a result clinicians have frequently been reluctant to administer this drug except in the presence of overt congestive heart failure or certain atrial arrhythmias. Most textbooks of pharmacology and cardiology state that digitalis reduces the cardiac output of both the normal and the enlarged nonfailing heart (1-9) by as much as 20 to 35% (4). Examination of the literature on which this idea is based reveals that the studies were frequently done under unphysiological conditions on heart-lung preparations (10) or in animals (11-13). SomeKeywords
This publication has 12 references indexed in Scilit:
- STUDIES ON DIGITALIS. II. EXTRACARDIAC EFFECTS ON VENOUS RETURN AND ON THE CAPACITY OF THE PERIPHERAL VASCULAR BEDJournal of Clinical Investigation, 1960
- Hemodynamic Effects of Cardiac Glycosides on Normal Human Subjects During Rest and ExerciseJournal of Applied Physiology, 1958
- Some Effects of Digoxin upon the Heart and Circulation in ManCirculation, 1950
- EFFECT OF LANATOSIDE C ON THE CIRCULATION OF PATIENTS WITH CONGESTIVE FAILUREArchives of Internal Medicine, 1948
- ACTION OF DIGITALIS IN COMPENSATED HEART DISEASEArchives of Internal Medicine, 1938
- STUDIES ON THE EFFECT OF THE ACTION OF DIGITALIS ON THE OUTPUT OF BLOOD FROM THE HEARTJournal of Clinical Investigation, 1932
- STUDIES ON THE EFFECT OF THE ACTION OF DIGITALIS ON THE OUTPUT OF BLOOD FROM THE HEART. III. 12Journal of Clinical Investigation, 1932
- FURTHER OBSERVATIONS ON THE CIRCULATORY ACTIONS OF DIGITALIS AND STROPHANTHUS WITH SPECIAL REFERENCE TO THE LIVER, AND COMPARISONS WITH HISTAMINE AND EPINEPHRINEJournal of Clinical Investigation, 1930
- THE CIRCULATORY CHANGES AFTER FULL THERAPEUTIC DOSES OF DIGITALIS, WITH A CRITICAL DISCUSSION OF VIEWS ON CARDIAC OUTPUT 1Journal of Clinical Investigation, 1930
- THE EFFECT OF DIGITALIS UPON THE OUTPUT OF THE HEART IN NORMAL MANJournal of Clinical Investigation, 1927