INHIBITION OF SPERMATOGENESIS IN THE RAT BY TREATMENT WITH [D-Ala6,DES-GLY-NH210]LHRH ETHYLAMIDE
- 1 August 1978
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 103 (2), 641-643
- https://doi.org/10.1210/endo-103-2-641
Abstract
The effect of treatment with a potent LHRH [luteinizing hormone releasing hormone] agonist, [D-Ala6, Des-Gly-NH210]LHRH ethylamide, injected at the low dose of 100 ng, twice a week, was evaluated on spermatogenesis in the rat. Significant degenerative changes of seminiferous tubules could be observed after 2 wk of treatment. These changes were progressive and led to a marked inhibition of spermatogenesis after 4-8 wk of treatment. Testis weight was decreased to approximately 50% of control after 8 wk of treatment.This publication has 3 references indexed in Scilit:
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