Dissolution from tablets prepared using ethyl cellulose microcapsules
- 1 September 1977
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 29 (1), 169-172
- https://doi.org/10.1111/j.2042-7158.1977.tb11276.x
Abstract
Microcapsules containing sodium phenobarbitone cores in ethyl cellulose have been used to prepare tablets at from 3·9 to 358·9 MPa compression pressures. The tensile strength of these tablets is related linearly to the core: wall ratio and to the microcapsule size. Dissolution of the drug from the microcapsules is also related to the core: wall ratio and microcapsule size, but except at low compression pressures is almost independent of the pressure used during preparation. The tablet matrix remains intact during the dissolution and the equations developed by Schwartz, Simonelli & Higuchi (1968) are followed. Large microcapsules of 1:2 core:wall ratio produce friable tablets with rapid release of contents.Keywords
This publication has 3 references indexed in Scilit:
- The in vitro dissolution of phenobarbitone sodium from ethyl cellulose microcapsulesJournal of Pharmacy and Pharmacology, 1976
- Determination of Tablet Strength by the Diametral-Compression TestJournal of Pharmaceutical Sciences, 1970
- Drug Release from Wax Matrices IJournal of Pharmaceutical Sciences, 1968