The effect of α,β-methylene ATP on the depolarization evoked by noradrenaline (γ-adrenoceptor response) and ATP in the immature rat basilar artery

Abstract

Depolarizations evoked by noradrenaline that were resistant to α- and β-adrenoceptor antagonists were recorded in the rat basilar artery. These γ-adrenoceptor-mediated responses and the depolarizations to adenosine triphosphate (ATP) were blocked by pretreatment of the tissue with α,β-methylene ATP. These data are discussed with respect to the selectivity of α,β-methylene ATP.