Correlation of Increased Vascular Endothelial Growth Factor With Neovascularization and Permeability in Ischemic Central Vein Occlusion

Abstract

VASCULAR endothelial growth factor (VEGF) is strongly suspected to be a key mediator of angiogenesis and increased vascular permeability in human diseases, including ocular neovascular disorders. Despite this, there are few opportunities in human disease to observe VEGF concentrations over time and to compare these data against the clinical onset, persistence, or regression of neovascularization, and changes in vasopermeability. Therefore, definitive evidence of the role of VEGF is lacking for many human neovascular diseases.