Effect of Epidermal Growth Factor in Severe Experimental Alkali Burns
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Ophthalmic Research
- Vol. 20 (5), 327-331
- https://doi.org/10.1159/000266738
Abstract
Ten rabbits with the right eye burnt by 1 N NaOH were treated 5 times daily with epidermal growth factor (EGF) eyedrops or placebo. The epithelium seemed to heal better under EGF treatment than with placebo. Also, ulceration and secondary calcification of the cornea were reduced in the EGF-treated group. The vascularisation was slightly diminished by EGF. The lactate dehydrogenase and N-acetylglucose aminidase activities and the lactate and glucose levels in the corneae were not different between the EGF and the placebo groups. The results showed that there was a beneficial effect of EGF in these experiments with most severe eye burn disease. But the improved regeneration of the epithelium seemed to be counteracted and partly abolished by the severe inflammatory reaction in these eyes.Keywords
This publication has 2 references indexed in Scilit:
- Enzymatic activity of β-N-acetylglucosaminidase in the alkali-burned rabbit corneaAlbrecht von Graefes Archiv für Ophthalmologie, 1982
- The effect of the epidermal growth factor (EGF) on the corneal epithelium in humansAlbrecht von Graefes Archiv für Ophthalmologie, 1979