Reduced frequencies of Mitomycin-C induced sister chromatid exchanges in AKR Mice
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 41 (1), 45-51
- https://doi.org/10.1007/bf00278870
Abstract
The frequencies of base-line and Mitomycin-C (MMC) induced sister chromatid exchanges (SCE) were surveyed in four inbred strains of mice. In contrast to the C57B1/6J, CBA/J, and A/J strains where frequencies of SCE increased linearly with increasing dose of MMC, levels of SCE were significantly lower in AKR/J mice at high MMC concentrations. At a dose of 5 mg/kg MMC, chromosomal aberrations were more frequent in bone marrow cells of AKR/J mice than in C57B1/6J mice. These observations suggest an altered response to DNA damage in the AKR mouse strain.This publication has 32 references indexed in Scilit:
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