Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon
- 1 April 2000
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 74 (7), 3404-3409
- https://doi.org/10.1128/jvi.74.7.3404-3409.2000
Abstract
We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.Keywords
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