Abstract
RESISTANT BACTERIA that can cause infections in the middle ear, nasal cavity, and respiratory system have been an increasing concern over the past 10 years. The rapid progression of the resistance of the 3 most common pathogens of otitis media and rhinosinusitis (Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis) has been alarming. In 1997, in more than 11 300 isolates evaluated from 434 institutions in 45 states and the district of Colombia, 30% to 40% of the H influenzae and S pneumoniae strains and 90% of the M catarrhalis strains were resistant.1