THE INFLUENCE OF SELECTED GOITROGENIC COMPOUNDS ON THE THYROID GLAND OF THE CHICK1

Abstract

A group of selected goitrogenic agents were tested for their relative effectiveness in young chicks. Thiouracil was used as the standard of reference, and its influence on the size of the thyroid gland and on the I content when fed for 14 days in concns. of 0.001% to 0.3% of the food provided the basis for comparison with other compounds similarly mixed in the food. Of the compounds tested, the derivatives of thiouracil with certain hydrocarbon groups substituted in position 6 were found most active. Derivatives of 4-amino-benzoic acid were found to have slight but definite activity. The admn. of thiouracil in maximal doses for 16 and 25 days did not prevent the rapid accumulation of iodide by the thyroid gland following the injn. of KI.