Genetic Control by the H-2 Gene Complex of the Alloantibody Response to an H-2 Antigen

Abstract

The genetic control of the immune response against an H-2 antigenic specificity was investigated. With the aid of five congenic mouse strains, B10.A, C57BL/10, B10.A(2R), B10.A(3R) and B10.A(5R), it was demonstrated that a genetic factor, possibly Ir-1, associated with the H-2(K) subdivision of the H-2^b chromosome, exerts a regulatory effect on a recipient's capacity to respond to H-2.2, an antigenic specificity determined by the H-2(D) subdivision of the H-2 gene complex.