Angiotensinogen in Human Essential Hypertension
- 1 December 1996
- journal article
- review article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 28 (6), 1123-1125
- https://doi.org/10.1161/01.hyp.28.6.1123
Abstract
The candidacy of angiotensinogen for a role in the genetic basis of hypertension is supported by the observation that plasma angiotensinogen levels track with raised blood pressure through families. In addition, transgenic mice with overexpression of a rat angiotensinogen gene develop hypertension, and knockout mice with a disrupted gene and absent angiotensinogen production develop low blood pressure. There are now two studies in populations of white European origin and one in African Caribbeans providing support for a role of the angiotensinogen gene locus in human essential hypertension.Keywords
This publication has 10 references indexed in Scilit:
- Genetic control of blood pressure and the angiotensinogen locus.Proceedings of the National Academy of Sciences, 1995
- Angiotensinogen gene in human hypertension. Lack of an association of the 235T allele among African Americans.Hypertension, 1994
- Genetic Dissection of Complex TraitsScience, 1994
- Linkage of the Angiotensinogen Gene to Essential HypertensionNew England Journal of Medicine, 1994
- Unlike human hypertension, blood pressure in a hereditary hypertensive rat strain shows no linkage to the angiotensinogen locus.Hypertension, 1994
- Angiotensinogen as a risk factor for essential hypertension in Japan.JCI Insight, 1994
- Cross-Sectional Analysis of Met235→Thr Variant of Angiotensinogen Gene in Severe, Familial HypertensionBiochemical and Biophysical Research Communications, 1993
- Molecular basis of human hypertension: Role of angiotensinogenCell, 1992
- Abnormalities of glucocorticoid metabolism and the renin???angiotensin system: a four-corners approach to the identification of genetic determinants of blood pressureJournal Of Hypertension, 1992
- Relation between blood pressure and renin, renin substrate, angiotensin II, aldosterone and urinary sodium and potassium in 574 ambulatory subjects.Hypertension, 1979