Defective Macrophage Function in a Patient with Common Variable Immunodeficiency

Abstract

COMMON variable immunodeficiency is characterized by different immunologic abnormalities responsible for agammaglobulinemia.¹ In this disease, impaired B-cell differentiation has been observed at different levels,² and defects of B-cell function in connection with abnormalities of regulatory T cells have been reported.^{3 4 5 6} Even though macrophages are known to play an essential part in the initiation and regulation of the immune response,⁷ a defect in macrophage function has not been identified in connection with common variable immunodeficiency.In this study, we report on a patient who, like most of our patients with common variable immunodeficiency, had a depressed T-cell proliferative response to Escherichia . . .