THE ABILITY OF 17-ETHYL-19-NORTESTOSTERONE TO BLOCK ETHIONINE-INDUCED FATTY LIVER IN RATS
- 1 October 1957
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 61 (4), 476-477
- https://doi.org/10.1210/endo-61-4-476
Abstract
Lipid infiltration of the liver caused by ethionine treatment of the castrate rat can be effectively blocked by certain testosterone derivatives as exemplified by 17-ethyl-19-nortestosterone at a dose that does not stimulate growth of secondary sex organs. The protective action of such a substance does not depend on progesterone-like action but upon a property apparently associated with its myotrophic activity. This supports the hypothesis that the major defect imposed by ethionine administration is one in protein metabolism secondary to which may be the alteration in lipid metabolism that was studied here.Keywords
This publication has 4 references indexed in Scilit:
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- THE MYOTROPHIC AND ANDROGENIC EFFECTS OF 17-ETHYL-19-NORTESTOSTERONE AND RELATED COMPOUNDSEndocrinology, 1956
- EFFECT OF ANDROGENS AND GROWTH AND OTHER HORMONES ON ETHIONINE FATTY LIVER IN RATSJournal of Biological Chemistry, 1955
- PREPARATION OF LIPIDE EXTRACTS FROM BRAIN TISSUEJournal of Biological Chemistry, 1951