Antiandrogenic Effects of Spironolactone: Hormonal and Ultrastructural Studies in Dogs and Men
- 1 March 1978
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 119 (3), 375-380
- https://doi.org/10.1016/s0022-5347(17)57495-9
Abstract
A decrease in the level of plasma testosterone and an increase in the level of plasma progesterone were noted after spironolactone had been administered for 20 days in 5 patients with prostatic carcinoma, as well as in 8 male dogs. Electron microscopic observation disclosed myelinlike bodies in the cytoplasm of Leydig and adrenocortical cells in dogs, contributing to a resolution of the mode of antiandrogenic action of spironolactone.This publication has 15 references indexed in Scilit:
- Effect of Spironolactone on Sex Hormones in ManJournal of Clinical Endocrinology & Metabolism, 1975
- Suppression of Plasma Androgens by Spironolactone in Castrated Men with Carcinoma of the ProstateJournal of Urology, 1975
- Spironolactone and cytochrome P-450: Impairment of steroid hydroxylation in the adrenal cortexLife Sciences, 1974
- Spironolactone and Testicular Cytochrome P-450: Decreased Testosterone Formation inSeveral Species and Changes in Hepatic Drug Metabolism1Endocrinology, 1974
- Adverse Reactions to SpironolactoneJAMA, 1973
- A double-blind, controlled, clinical trial of spironolactone for benign prostatic hypertrophyBritish Journal of Surgery, 1971
- Spironolactone Therapy and GynecomastiaJAMA, 1965
- Gynecomastia During Therapy with SpironolactoneJAMA, 1963
- SPIRONOLACTONE AND GYNÆCOMASTIAThe Lancet, 1962
- SPIRONOLACTONE AND GYNÆCOMASTIAThe Lancet, 1962