New Enantioselective Reactions catalysed by cinchonidine-modified platinum

Abstract

The conjugated diketones butane-2,3-dione and hexane-3,4-dione can be hydrogenated enantioselectively over Pt/silica modified by cinchonidine giving enantiomeric excesses in favour of (R)-(–)-3-hydroxybutan-2-one of up to 38% and of (R)-(-)-4-hydroxyhexan-3-one up to 33%.