Antidepressants Alter Cerebrovascular Permeability and Metabolic Rate in Primates
- 16 July 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 217 (4556), 250-252
- https://doi.org/10.1126/science.7089562
Abstract
External detection of the annihilation radiation produced by water labeled with oxygen-15 was used to measure cerebrovascular permeability and cerebral blood flow in six rhesus monkeys. Use of oxygen-15 also permitted assessment of cerebral metabolic rate in two of the monkeys. Amitriptyline produced a dose-dependent, reversible increase in permeability at plasma drug concentrations which are therapeutic for depressed patients. At the same concentrations the drug also produced a 20 to 30 percent reduction in cerebral metabolic rate. At higher doses normal autoregulation of cerebral blood flow was suspended, but responsivity to arterial carbon dioxide was normal.This publication has 14 references indexed in Scilit:
- Brain concentrations of tricyclic antidepressants: Single-dose kinetics and relationship to plasma concentrations in chronically dosed ratsPsychopharmacology, 1982
- A liquid chromatographic method for quantitating amitriptyline in brain tissuePsychopharmacology, 1982
- The significance of the NH3-NH+(4) equilibrium on the passage of 13N-ammonia from blood to brain. A new regional residue detection model.Circulation Research, 1981
- Modulation of lateral geniculate neurone excitability by noradrenaline microiontophoresis or locus coeruleus stimulationNature, 1980
- Liquid chromatography of amitriptyline and related tricyclic compoundsJournal of Chromatography A, 1980
- Long-term antidepressant treatment: Alterations in cerebral capillary permeabilityPsychopharmacology, 1980
- Amitriptyline plasma levels and therapeutic responseClinical Pharmacology & Therapeutics, 1976
- Effects of increased intracranial pressure on cerebral blood volume, blood flow, and oxygen utilization in monkeysJournal of Neurosurgery, 1975
- Evidence of the Limitations of Water as a Freely Diffusible Tracer in Brain of the Rhesus MonkeyCirculation Research, 1974
- The Permeability of Capillaries in Various Organs as Determined by Use of the ‘Indicator Diffusion’ MethodActa Physiologica Scandinavica, 1963