Review of local soft tissue recurrence of breast cancer irradiated with and without actinomycin-D

Abstract
Between 1962 and 1973, regionally recurrent breast cancer was treated in 156 patients by irradiation alone or irradiation with concurrent actinomycin‐D. Thirty‐two patients were entered into a randomized trial, and 124 patients were retrospectively reviewed. Local control with irradiation alone was achieved in 48 of 80 patients (60%) and in 60 of 76 patients (79%) treated with irradiation and actinomycin‐D (p < .05). Results were remarkably similar in the randomized and retrospective series.